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Face of Tobias Ambjörnsson. Photo.

Tobias Ambjörnsson

Senior lecturer

Face of Tobias Ambjörnsson. Photo.

Single DNA conformations and biological function

Author

  • Ralf Metzler
  • Tobias Ambjörnsson
  • Andreas Hanke
  • Yongli Zhang
  • Stephen Levene

Summary, in English

From a nanoscience perspective, cellular processes and their reduced in vitro imitations provide extraordinary examples for highly robust few or single molecule reaction pathways. A prime example are biochemical reactions involving DNA molecules, and the coupling of these reactions to the physical conformations of DNA. In this review, we summarise recent results on the following phenomena: We investigate the biophysical properties of DNA-looping and the equilibrium configurations of DNA-knots, whose relevance to biological processes are increasingly appreciated. We discuss how random DNA-looping may be related to the efficiency of the target search process of proteins for their specific binding site on the DNA molecule. And we dwell on the spontaneous formation of intermittent DNA nanobubbles and their importance for biological processes, such as transcription initiation. The physical properties of DNA may indeed turn out to be particularly suitable for the use of DNA in nanosensing applications.

Publishing year

2007-01-01

Language

English

Pages

1-49

Publication/Series

Journal of Computational and Theoretical Nanoscience

Volume

4

Issue

1

Document type

Journal article review

Publisher

American Scientific Publishers

Keywords

  • DNA
  • DNA denaturation
  • DNA looping
  • Gene regulation
  • Knots
  • Single molecules

Status

Published

ISBN/ISSN/Other

  • ISSN: 1546-1955