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Face of Tobias Ambjörnsson. Photo.

Tobias Ambjörnsson

Senior lecturer

Face of Tobias Ambjörnsson. Photo.

Bubble coalescence in breathing DNA: Two vicious walkers in opposite potentials

Author

  • T. Novotny
  • Jonas Pedersen
  • T. Ambjörnsson
  • M. S. Hansen
  • R. Metzler

Summary, in English

We investigate the coalescence of two DNA bubbles initially located at weak segments and separated by a more stable barrier region in a designed construct of double-stranded DNA. The characteristic time for bubble coalescence and the corresponding distribution are derived, as well as the distribution of coalescence positions along the barrier. Below the melting temperature, we find a Kramers-type barrier crossing behaviour, while at high temperatures, the bubble corners perform drift-diffusion towards coalescence. The results are obtained by mapping the bubble dynamics on the problem of two vicious walkers in opposite potentials.

Department/s

  • Mathematical Physics

Publishing year

2007

Language

English

Publication/Series

Europhysics Letters

Volume

77

Issue

4

Document type

Journal article

Publisher

EDP Sciences

Topic

  • Physical Sciences

Status

Published

ISBN/ISSN/Other

  • ISSN: 0295-5075