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Mattias Ohlsson

Mattias Ohlsson

Professor

Mattias Ohlsson

Method for protein structure alignment

Other contributions

  • Mattias Ohlsson
  • Carsten Peterson
  • Markus Ringnér
  • Richard Blankenbecler

Summary, in English

This invention provides a method for protein structure alignment. More particularly, the present invention provides a method for identification, classification and prediction of protein structures. The present invention involves two key ingredients. First, an energy or cost function formulation of the problem simultaneously in terms of binary (Potts) assignment variables and real-valued atomic coordinates. Second, a minimization of the energy or cost function by an iterative method, where in each iteration (1) a mean field method is employed for the assignment variables and (2) exact rotation and/or translation of atomic coordinates is performed, weighted with the corresponding assignment variables.

Department/s

  • Computational Biology and Biological Physics

Publishing year

2005-02-22

Language

English

Document type

Patent

Topic

  • Bioinformatics and Systems Biology

Status

Published