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Mattias Ohlsson

Mattias Ohlsson

Professor

Mattias Ohlsson

Automated interpretation of PET/CT images in patients with lung cancer.

Author

  • Henrik Gutte
  • David Jakobsson
  • Fredrik Olofsson
  • Mattias Ohlsson
  • Sven Valind
  • Annika Loft
  • Lars Edenbrandt
  • Andreas Kjær

Summary, in English

Purpose: To develop a completely automated method based on image processing techniques and artificial neural networks for the interpretation of combined [18F]fluorodeoxyglucose (FDG) positron emission tomography (PET) and computed tomography (CT) images for the diagnosis and staging of lung cancer.



Methods: A total of 87 patients who underwent PET/CT examinations due to suspected lung cancer comprised the training group. The test group consisted of PET/CT images from 49 patients suspected with lung cancer. The consensus interpretations by two experienced physicians were used as the 'gold standard' image interpretation. The training group was used in the development of the automated method. The image processing techniques included algorithms for segmentation of the lungs based on the CT images and detection of lesions in the PET images. Lung boundaries from the CT images were used for localization of lesions in the PET images in the feature extraction process. Eight features from each examination were used as inputs to artificial neural networks trained to classify the images. Thereafter, the performance of the network was evaluated in the test set.



Results: The performance of the automated method measured as the area under the receiver operating characteristic curve, was 0.97 in the test group, with an accuracy of 92%. The sensitivity was 86% at a specificity of 100%.



Conclusions: A completely automated method using artificial neural networks can be used to detect lung cancer with such a high accuracy that the application as a clinical decision support tool appears to have significant potential.

Department/s

  • Computational Biology and Biological Physics
  • Clinical Physiology, Malmö
  • Department of Translational Medicine

Publishing year

2007

Language

English

Pages

79-84

Publication/Series

Nuclear Medicine Communications

Volume

28

Issue

2

Document type

Journal article

Publisher

Lippincott Williams & Wilkins

Topic

  • Radiology, Nuclear Medicine and Medical Imaging

Status

Published

Research group

  • Clinical Physiology, Malmö

ISBN/ISSN/Other

  • ISSN: 1473-5628