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Mattias Ohlsson

Mattias Ohlsson

Professor

Mattias Ohlsson

Genetic profiles of gastroesophageal cancer: combined analysis using expression array and tiling array-comparative genomic hybridization

Author

  • Anna Isinger Ekstrand
  • Jan Johansson
  • Mattias Ohlsson
  • Princy Francis
  • Johan Staaf
  • Mats Jönsson
  • Åke Borg
  • Mef Nilbert

Summary, in English

We aimed to characterize the genomic profiles of adenocarcinomas in the gastroesophageal junction in relation to cancers in the esophagus and the stomach. Profiles of gains/losses as well as gene expression profiles were obtained from 27 gastroesophageal adenocarcinomas by means of 32k high-resolution array-based comparative genomic hybridization and 27k oligo gene expression arrays, and putative target genes were validated in an extended series. Adenocarcinomas in the distal esophagus and the gastroesophageal junction showed strong similarities with the most common gains at 20q13, 8q24, 1q21-23, 5p15, 13q34, and 12q13, whereas different profiles with gains at 5p15, 7p22, 2q35, and 13q34 characterized gastric cancers. CDK6 and EGFR were identified as putative target genes in cancers of the esophagus and the gastroesophageal junction, with upregulation in one quarter of the tumors. Gains/losses and gene expression profiles show strong similarity between cancers in the distal esophagus and the gastroesophageal junction with frequent upregulation of CDK6 and EGFR, whereas gastric cancer displays distinct genetic changes. These data suggest that molecular diagnostics and targeted therapies can be applied to adenocarcinomas of the distal esophagus and gastroesophageal junction alike. (C) 2010 Elsevier Inc. All rights reserved.

Department/s

  • Department of Immunotechnology
  • Surgery (Lund)
  • Computational Biology and Biological Physics
  • Breastcancer-genetics
  • EpiHealth: Epidemiology for Health
  • BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation

Publishing year

2010

Language

English

Pages

120-126

Publication/Series

Cancer Genetics and Cytogenetics

Volume

200

Issue

2

Document type

Journal article

Publisher

Elsevier

Topic

  • Cancer and Oncology
  • Surgery

Keywords

  • Esophageal Neoplasms: genetics
  • Oligonucleotide Array Sequence Analysis: methods
  • Comparative Genomic Hybridization: methods
  • Cyclin-Dependent Kinase 6: genetics
  • Receptor
  • Epidermal Growth Factor: genetics
  • Stomach Neoplasms: genetics

Status

Published

ISBN/ISSN/Other

  • ISSN: 0165-4608