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Mattias Ohlsson

Mattias Ohlsson

Professor

Mattias Ohlsson

Evaluation of a previously suggested plasma biomarker panel to identify Alzheimer's disease.

Author

  • Maria Björkqvist
  • Mattias Ohlsson
  • Lennart Minthon
  • Oskar Hansson

Summary, in English

There is an urgent need for biomarkers in plasma to identify Alzheimer's disease (AD). It has previously been shown that a signature of 18 plasma proteins can identify AD during pre-dementia and dementia stages (Ray et al, Nature Medicine, 2007). We quantified the same 18 proteins in plasma from 174 controls, 142 patients with AD, and 88 patients with other dementias. Only three of these proteins (EGF, PDG-BB and MIP-1δ) differed significantly in plasma between controls and AD. The 18 proteins could classify patients with AD from controls with low diagnostic precision (area under the ROC curve was 63%). Moreover, they could not distinguish AD from other dementias. In conclusion, independent validation of results is important in explorative biomarker studies.

Department/s

  • Biomarkers in Brain Disease
  • Computational Biology and Biological Physics
  • Clinical Memory Research
  • MultiPark: Multidisciplinary research focused on Parkinson´s disease

Publishing year

2012

Language

English

Publication/Series

PLoS ONE

Volume

7

Issue

1

Document type

Journal article

Publisher

Public Library of Science

Topic

  • Neurology
  • Neurosciences

Status

Published

Research group

  • Biomarkers in Brain Disease
  • Clinical Memory Research

ISBN/ISSN/Other

  • ISSN: 1932-6203