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Mattias Ohlsson

Mattias Ohlsson

Professor

Mattias Ohlsson

Identification of B-cell lymphoma subsets by plasma protein profiling using recombinant antibody microarrays.

Author

  • Frida Pauly
  • Karin E Smedby
  • Mats Jerkeman
  • Henrik Hjalgrim
  • Mattias Ohlsson
  • Richard Rosenquist
  • Carl A K Borrebaeck
  • Christer Wingren

Summary, in English

B-cell lymphoma (BCL) heterogeneity represents a key issue, often making the classification and clinical management of these patients challenging. In this pilot study, we outlined the first resolved view of BCL disease heterogeneity on the protein level by deciphering disease-associated plasma biomarkers, specific for chronic lymphocytic leukemia, diffuse large B-cell lymphoma, follicular lymphoma, and mantle cell lymphoma, using recombinant antibody microarrays targeting mainly immunoregulatory proteins. The results showed the BCLs to be heterogeneous, and revealed potential novel subgroups of each BCL. In the case of diffuse large B-cell lymphoma, we also indicated a link between the novel subgroups and survival.

Department/s

  • Department of Immunotechnology
  • BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
  • Department of Astronomy and Theoretical Physics
  • Create Health

Publishing year

2014

Language

English

Pages

682-690

Publication/Series

Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis

Volume

38

Issue

6

Document type

Journal article

Publisher

Elsevier

Topic

  • Cancer and Oncology

Status

Published

ISBN/ISSN/Other

  • ISSN: 1873-5835