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Anders Irbäck. Photo.

Anders Irbäck

Professor

Anders Irbäck. Photo.

Binary assignments of amino acids from pattern conservation

Author

  • A Irbäck
  • F Potthast

Summary, in English

We have developed a simple optimization procedure for assigning binary values to amino acids. The binary values are determined by a maximization of the degree of pattern conservation in groups of closely related protein sequences. The maximization is carried out at fixed composition. For compositions approximately corresponding to an equipartition of the residues, the optimal encoding is found to be strongly correlated with hydrophobicity. The stability of the procedure is demonstrated. Our calculations are based upon sequences in the SWISS-PROT database.

Department/s

  • Computational Biology and Biological Physics

Publishing year

1997-09

Language

English

Pages

1013-1017

Publication/Series

Protein Engineering

Volume

10

Issue

9

Document type

Journal article

Publisher

Oxford University Press

Keywords

  • Amino Acids
  • Databases, Factual
  • Fourier Analysis
  • Models, Chemical
  • Peptide Mapping
  • Protein Folding
  • Proteins

Status

Published

ISBN/ISSN/Other

  • ISSN: 0269-2139