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Anders Irbäck. Photo.

Anders Irbäck

Professor

Anders Irbäck. Photo.

Differences in solution behavior among four semiconductor-binding peptides

Author

  • Simon Mitternacht
  • Stefan Schnabel
  • Michael Bachmann
  • Wolfhard Janke
  • Anders Irbäck

Summary, in English

Recent experiments have identified peptides that adhere to GaAs and Si surfaces. Here, we use all-atom Monte Carlo simulations with implicit solvent to investigate the behavior in aqueous solution of four such peptides, all with 12 residues. At room temperature, we find that all four peptides are largely unstructured, which is consistent with experimental data. At the same time, we find that one of the peptides is structurally different and more flexible, as compared to the others. This finding points at structural differences as a possible explanation for differences in adhesion properties among these peptides. By also analyzing designed mutants of two of the peptides, an experimental test of this hypothesis is proposed.

Department/s

  • Computational Biology and Biological Physics

Publishing year

2007

Language

English

Pages

4355-4360

Publication/Series

The Journal of Physical Chemistry Part B

Volume

111

Issue

17

Document type

Journal article

Publisher

The American Chemical Society (ACS)

Topic

  • Biophysics

Status

Published

ISBN/ISSN/Other

  • ISSN: 1520-5207