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Anders Irbäck. Photo.

Anders Irbäck

Professor

Anders Irbäck. Photo.

Protein folding/unfolding in the presence of interacting macromolecular crowders

Author

  • Anders Irbäck
  • Sandipan Mohanty

Summary, in English

Recent years have seen an increasing number of biophysical studies of proteins being conducted in cells and concentrated protein solutions. In these experiments, compared to dilute-solution data, both stabilization and destabilization of globular proteins have been observed, which cannot be explained in terms of volume exclusion alone. For a fundamental understanding of the observed effects, there is a need for computational modeling beyond the level of hard-sphere crowders. This mini-review discusses recent efforts to simulate folding/unfolding properties of proteins in the presence of explicit macromolecular crowders. A Monte Carlo-based approach by us is described, which we recently applied to study the equilibrium folding thermodynamics of two peptides in the presence of explicit protein crowders.

Department/s

  • Computational Biology and Biological Physics

Publishing year

2017-04-01

Language

English

Pages

627-638

Publication/Series

European Physical Journal: Special Topics

Volume

226

Issue

4

Document type

Journal article review

Publisher

Springer

Topic

  • Other Physics Topics
  • Biophysics

Status

Published

ISBN/ISSN/Other

  • ISSN: 1951-6355